Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to condition dendritic cells (DCs) to prime Th2 responses. However, the molecular mechanisms underlying this effect remain unknown. We show in t...

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Main Authors: Everts, Bart, Hussaarts, Leonie, Driessen, Nicole N., Meevissen, Moniek H.J., Schramm, Gabriele, van der Ham, Alwin J., van der Hoeven, Barbara, Scholzen, Thomas, Burgdorf, Sven, Mohrs, Markus, Pearce, Edward J., Hokke, Cornelis H., Haas, Helmut, Smits, Hermelijn H., Yazdanbakhsh, Maria
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457738/
https://ncbi.nlm.nih.gov/pubmed/22966004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111381
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