Effects of light irradiation upon photodynamic therapy based on 5-aminolevulinic acid–gold nanoparticle conjugates in K562 cells via singlet oxygen generation

PURPOSE: As a precursor of the potent photosensitizer protoporphyrin IX (PpIX), 5-aminolevulinic acid (5-ALA), was conjugated onto cationic gold nanoparticles (GNPs) to improve the efficacy of photodynamic therapy (PDT). METHODS: Cationic GNPs reduced by branched polyethyleneimine and 5-ALA were con...

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Autori principali: Xu, Hao, Liu, Chen, Mei, Jiansheng, Yao, Cuiping, Wang, Sijia, Wang, Jing, Li, Zheng, Zhang, Zhenxi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2012
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457679/
https://ncbi.nlm.nih.gov/pubmed/23055721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S33261
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