Epigenetic Control of Cell Cycle-Dependent Histone Gene Expression Is a Principal Component of the Abbreviated Pluripotent Cell Cycle

Self-renewal of human pluripotent embryonic stem cells proceeds via an abbreviated cell cycle with a shortened G(1) phase. We examined which genes are modulated in this abbreviated period and the epigenetic mechanisms that control their expression. Accelerated upregulation of genes encoding histone...

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Main Authors: Medina, Ricardo, Ghule, Prachi N., Cruzat, Fernando, Barutcu, A. Rasim, Montecino, Martin, Stein, Janet L., van Wijnen, Andre J., Stein, Gary S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457543/
https://ncbi.nlm.nih.gov/pubmed/22826438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00736-12
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