Identification of a Gene Involved in the Synthesis of a Dipeptidyl Peptidase IV Inhibitor in Aspergillus oryzae

WYK-1 is a dipeptidyl peptidase IV inhibitor produced by Aspergillus oryzae strain AO-1. Because WYK-1 is an isoquinoline derivative consisting of three l-amino acids, we hypothesized that a nonribosomal peptide synthetase was involved in its biosynthesis. We identified 28 nonribosomal peptide synth...

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Bibliographic Details
Main Authors: Imamura, Kazuhiko, Tsuyama, Yoshihito, Hirata, Terukage, Shiraishi, Sumihiro, Sakamoto, Kazutoshi, Yamada, Osamu, Akita, Osamu, Shimoi, Hitoshi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457513/
https://ncbi.nlm.nih.gov/pubmed/22843525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01770-12
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