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Pharmacodynamics of the Antibacterial Effect of and Emergence of Resistance to Doripenem in Pseudomonas aeruginosa and Acinetobacter baumannii in an In Vitro Pharmacokinetic Model

An in vitro dilutional pharmacokinetic model of infection was used to study the pharmacodynamics of doripenem in terms of the ability to kill Pseudomonas aeruginosa or Acinetobacter baumannii and also changes in their population profiles. In dose-ranging studies, the cumulative percentages of a 24-h...

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Detalhes bibliográficos
Main Authors: Bowker, Karen E., Noel, Alan R., Tomaselli, Sharon G., Elliott, Heather, MacGowan, Alasdair P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457408/
https://ncbi.nlm.nih.gov/pubmed/22713338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06111-11
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