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In Vitro and In Vivo Characterization of CB-183,315, a Novel Lipopeptide Antibiotic for Treatment of Clostridium difficile

CB-183,315 is a novel lipopeptide antibiotic structurally related to daptomycin currently in phase 3 clinical development for Clostridium difficile-associated diarrhea (CDAD). We report here the in vitro mechanism of action, spontaneous resistance incidence, resistance by serial passage, time-kill k...

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Detalhes bibliográficos
Main Authors: Mascio, Carmela T. M., Mortin, Lawrence I., Howland, Karen T., Van Praagh, Andrew D. G., Zhang, Shuxin, Arya, Anu, Chuong, Cun Lan, Kang, Chunfeng, Li, Tongchuan, Silverman, Jared A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457379/
https://ncbi.nlm.nih.gov/pubmed/22802252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00057-12
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