γ-Glutamyl Spermine Synthetase PauA2 as a Potential Target of Antibiotic Development against Pseudomonas aeruginosa

Polyamines are absolute requirements for cell growth. When in excess, Pseudomonas aeruginosa possesses six γ-glutamylpolyamine synthetases (GPSs) encoded by the pauA1-pauA7 genes to initiate polyamine catabolism. Recently, the pauA2 mutant was reported to lose the capability to grow on spermine (Spm...

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Main Authors: Yao, Xiangyu, Li, Congran, Zhang, Jianmei, Lu, Chung-Dar
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457366/
https://ncbi.nlm.nih.gov/pubmed/22869561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01158-12
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