Site-Specific Cleavage of the Host Poly(A) Binding Protein by the Encephalomyocarditis Virus 3C Proteinase Stimulates Viral Replication

Although picornavirus RNA genomes contain a 3′-terminal poly(A) tract that is critical for their replication, the impact of encephalomyocarditis virus (EMCV) infection on the host poly(A)-binding protein (PABP) remains unknown. Here, we establish that EMCV infection stimulates site-specific PABP pro...

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Main Authors: Kobayashi, Mariko, Arias, Carolina, Garabedian, Alexandra, Palmenberg, Ann C., Mohr, Ian
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457283/
https://ncbi.nlm.nih.gov/pubmed/22837200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00896-12
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