Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci

Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A con...

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Hlavní autoři: Fros, Jelke J., Domeradzka, Natalia E., Baggen, Jim, Geertsema, Corinne, Flipse, Jacky, Vlak, Just M., Pijlman, Gorben P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457282/
https://ncbi.nlm.nih.gov/pubmed/22837213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01506-12
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