A Quantitative Measurement of Antiviral Activity of Anti-Human Immunodeficiency Virus Type 1 Drugs against Simian Immunodeficiency Virus Infection: Dose-Response Curve Slope Strongly Influences Class-Specific Inhibitory Potential

Simian immunodeficiency virus (SIV) infection in macaques is so far the best animal model for human immunodeficiency virus type 1 (HIV-1) studies, but suppressing viral replication in infected animals remains challenging. Using a novel single-round infectivity assay, we quantitated the antiviral act...

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Detalhes bibliográficos
Main Authors: Deng, Kai, Zink, M. Christine, Clements, Janice E., Siliciano, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457139/
https://ncbi.nlm.nih.gov/pubmed/22875968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01563-12
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