Direct conversion of an oligopeptide from a β-sheet to an α-helix: A model for amyloid formation
A 16-amino acid oligopeptide forms a stable β-sheet structure in water. In physiological solutions it is able to self-assemble to form a macroscopic matrix that stains with Congo red. On raising the temperature of the aqueous solution above 70°C, an abrupt structural transition occurs in the CD spec...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34557/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8990154/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.1.23 |
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