Tumors undergoing rejection induced by monoclonal antibodies of the IgG2a isotype contain increased numbers of macrophages activated for a distinctive form of antibody-dependent cytolysis.

Monoclonal antibodies of the IgG2a isotype specifically inhibit the growth of human tumors in nude mice; tumors in mice given no antibody, an antibody of the IgG2a isotype that does bind to the tumor cells, or an antibody of the IgG2b isotype grow progressively. In the present work it is demonstrate...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Adams, D O, Hall, T, Steplewski, Z, Koprowski, H
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1984
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345537/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6587365/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.11.3506
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