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Metabolic mechanisms of longevity: Caloric restriction in mammals and longevity mutations in Caenorhabditis elegans; a common pathway??
Several recent studies in Caenorhabditis elegans have reported significant extension of the lifespan by probable loss of function mutations in various genes. When sequenced, many of these genes exhibited significant homology to genes in the mammalian insulin signaling cascade. For example, the daf-2...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Kluwer Academic Publishers
2000
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3455360/ https://ncbi.nlm.nih.gov/pubmed/23604793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-000-0001-1 |
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