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Hyperactive BMP signaling induced by ALK2(R206H) requires type II receptor function in a Drosophila model for classic Fibrodysplasia Ossificans Progressiva
Fibrodysplasia Ossificans Progressiva (FOP) is an autosomal dominant skeletal disorder characterized by widespread and debilitating bone formation in place of soft connective tissue. All mutations associated with FOP map to the BMP type I receptor, ALK2, with the vast majority of patients possessing...
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| Main Authors: | , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2012
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3454517/ https://ncbi.nlm.nih.gov/pubmed/22174087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22779 |
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