Herpes Simplex Virus 1 ICP22 Inhibits the Transcription of Viral Gene Promoters by Binding to and Blocking the Recruitment of P-TEFb

ICP22 is a multifunctional herpes simplex virus 1 (HSV-1) immediate early protein that functions as a general repressor of a subset of cellular and viral promoters in transient expression systems. Although the exact mechanism of repression remains unclear, this protein induces a decrease in RNA poly...

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Detalhes bibliográficos
Main Authors: Guo, Lei, Wu, Wen-juan, Liu, Long-ding, Wang, Li-chun, Zhang, Ying, Wu, Lian-qiu, Guan, Ying, Li, Qi-han
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454370/
https://ncbi.nlm.nih.gov/pubmed/23029222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045749
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