Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

Low density lipoprotein (LDL) incubated with cultured endothelial cells from rabbit aorta or human umbilical vein is altered in several ways (EC-modified): (i) It is degraded by macrophages much faster than LDL similarly incubated in the absence of cells or incubated with fibroblasts. (ii) Its elect...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Steinbrecher, U P, Parthasarathy, S, Leake, D S, Witztum, J L, Steinberg, D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345326/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6587396/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.12.3883
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