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Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester.

Treatment of human K562 cells with 4 beta-phorbol 12-myristate 13-acetate (PMA) resulted in an approximately 50% reduction in cell surface transferrin receptors within 30-45 min as judged by binding of both ligand and anti-receptor antibody. The affinity of the remaining surface receptors for diferr...

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Hlavní autoři: Klausner, R D, Harford, J, van Renswoude, J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1984
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC345209/
https://ncbi.nlm.nih.gov/pubmed/6328486
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