Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture.

Four methotrexate (MTX)-resistant sublines of a human squamous cell carcinoma (SCC15) were established in culture by progressive dose escalation. The biochemical basis of resistance was studied. The line with the lowest resistance (R1) had a normal dihydrofolate reductase (DHFR) content but showed d...

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Autori principali: Frei, E, Rosowsky, A, Wright, J E, Cucchi, C A, Lippke, J A, Ervin, T J, Jolivet, J, Haseltine, W A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1984
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC345174/
https://ncbi.nlm.nih.gov/pubmed/6201865
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