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Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP
In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug resistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Kluwer Academic Publishers
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449569/ https://ncbi.nlm.nih.gov/pubmed/19002788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1008004502861 |
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