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Na-butyrate increases the production and α2,6-sialylation of recombinant interferon-γ expressed by α2,6- sialyltransferase engineered CHO cells

A non-human like glycosylation pattern in human recombinant glycoproteins expressed by animal cells may compromise their use as therapeutic drugs. In order to correct the CHO glycosylation machinery, a CHO cell line producing recombinant human interferon- γ (IFN) was transformed to replace the endog...

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Bibliografske podrobnosti
Main Authors: Lamotte, Damien, Buckberry, Lorraine, Monaco, Lucia, Soria, Marco, Jenkins, Nigel, Engasser, Jean-Marc, Marc, Annie
Format: Artigo
Jezik:Inglês
Izdano: Kluwer Academic Publishers 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449462/
https://ncbi.nlm.nih.gov/pubmed/19003337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1008080432681
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