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RS-Predictor models augmented with SMARTCyp reactivities: Robust metabolic regioselectivity predictions for nine CYP isozymes

RS-Predictor is a tool for creating pathway-independent, isozyme-specific site of metabolism (SOM) prediction models using any set of known cytochrome P450 substrates and metabolites. Until now, the RS-Predictor method was only trained and validated on CYP 3A4 data, but in the present study we repor...

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Detaylı Bibliyografya
Asıl Yazarlar: Zaretzki, Jed, Rydberg, Patrik, Bergeron, Charles, Bennett, Kristin P., Olsen, Lars, Breneman, Curt M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449220/
https://ncbi.nlm.nih.gov/pubmed/22524152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300009z
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