Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease

Aims: The human LRRK2 gene has been identified as the most common causative gene of autosomal-dominantly inherited and idiopathic Parkinson disease (PD). The G2019S substitution is the most common mutation in LRRK2. The R1441C mutation also occurs in cases of familial PD, but is not as prevalent. So...

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Autores principales: Di Domenico, Fabio, Sultana, Rukhsana, Ferree, Andrew, Smith, Katelyn, Barone, Eugenio, Perluigi, Marzia, Coccia, Raffaella, Pierce, William, Cai, Jian, Mancuso, Cesare, Squillace, Rachel, Wiengele, Manfred, Dalle-Donne, Isabella, Wolozin, Benjamin, Butterfield, D. Allan
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
Materias:
Forum Original Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448940/
https://ncbi.nlm.nih.gov/pubmed/22315971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4312
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