Modulation of PAR(1) signalling by benzimidazole compounds

BACKGROUND AND PURPOSE: Recently, a small molecule (Q94) was reported to selectively block PAR(1)/Gα(q) interaction and signalling. Here, we describe the pharmacological properties of Q94 and two analogues that share its benzimidazole scaffold (Q109, Q89). Q109 presents a modest variation from Q94 i...

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Detalhes bibliográficos
Main Authors: Asteriti, S, Daniele, S, Porchia, F, Dell' Anno, MT, Fazzini, A, Pugliesi, I, Trincavelli, ML, Taliani, S, Martini, C, Mazzoni, MR, Gilchrist, A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448915/
https://ncbi.nlm.nih.gov/pubmed/22519452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01974.x
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