Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.

We have visualized angiotensin-converting enzyme (ACE; dipeptidyl carboxypeptidase, peptidylpeptide hydrolase, EC 3.4.15.1) in rat brain by in vitro [3H]captopril autoradiography. [3H]Captopril binding to brain slices displays a high affinity (Kd = 1.8 X 10(-9) M) and a pharmacological profile simil...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Strittmatter, S M, Lo, M M, Javitch, J A, Snyder, S H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6324207/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.5.1599
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