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Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells

Renal fibrosis (RF) is thought to be a direct consequence of dedifferentiation of resident epithelial cells via an epithelial-mesenchymal transition (EMT). Increased glomerular flow is a critical initiator of fibrogenesis. Yet, the responses of proximal tubular epithelial cells (PTECs) to fluid flow...

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Sonraí Bibleagrafaíochta
Main Authors: Grabias, Bryan M., Konstantopoulos, Konstantinos
Formáid: Artigo
Teanga:Inglês
Foilsithe: Federation of American Societies for Experimental Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448778/
https://ncbi.nlm.nih.gov/pubmed/22744866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-207324
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