Sirtuin 1 Facilitates Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts through the miR-34a and p53 Pathways

Forced-expression of transcription factors can reprogram somatic cells into induced pluripotent stem cells (iPSC). Recent studies show that the reprogramming efficiency can be improved by inclusion of small molecules that regulate chromatin modifying enzymes. We report here that sirtuin 1 (SIRT1), a...

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Main Authors: Lee, Yin Lau, Peng, Qian, Fong, Sze Wan, Chen, Andy C. H., Lee, Kai Fai, Ng, Ernest H. Y., Nagy, Andras, Yeung, William S. B.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448677/
https://ncbi.nlm.nih.gov/pubmed/23029150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045633
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