Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer

MicroRNAs (miRNAs) are small non-coding RNAs of ∼20 nt in length that are capable of modulating gene expression post-transcriptionally. Although miRNAs have been implicated in cancer, including breast cancer, the regulation of miRNA transcription and the role of defects in this process in cancer is...

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Detalhes bibliográficos
Main Authors: Wee, E J H, Peters, K, Nair, S S, Hulf, T, Stein, S, Wagner, S, Bailey, P, Lee, S Y, Qu, W J, Brewster, B, French, J D, Dobrovic, A, Francis, G D, Clark, S J, Brown, M A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448136/
https://ncbi.nlm.nih.gov/pubmed/22231446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.584
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