Crystal Structures of Human CaMKIα Reveal Insights into the Regulation Mechanism of CaMKI

Human calcium/calmodulin-dependent protein kinase I (CaMKI) plays pivotal roles in the nervous system. The activity of human CaMKI is regulated by a regulatory region including an autoinhibitory segment and a CaM-binding segment. We report here four structures of three CaMKIα truncates in apo form a...

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Bibliographic Details
Main Authors: Zha, Manwu, Zhong, Chen, Ou, Ying, Han, Li, Wang, Jianchuan, Ding, Jianping
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447817/
https://ncbi.nlm.nih.gov/pubmed/23028635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044828
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