Valproic Acid Downregulates RBP4 and Elicits Hypervitaminosis A-Teratogenesis—A Kinetic Analysis on Retinol/Retinoic Acid Homeostatic System

BACKGROUND: Valproic acid (VPA) is an antiepileptic and anti-migraine prophylactic drug. VPA exhibits two severe side effects, namely acute liver toxicity and teratogenicity. These side effects are usually seen at the genetic and somatic levels. The cited action mechanisms involve inhibition of hist...

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Detalhes bibliográficos
Main Authors: Chuang, Chao-Ming, Chang, Chi-Huang, Wang, Hui-Er, Chen, Kuan-Chou, Peng, Chiung-Chi, Hsieh, Chiu-Lan, Peng, Robert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446952/
https://ncbi.nlm.nih.gov/pubmed/23028466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043692
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