Treatment with Activated Protein C (aPC) Is Protective during the Development of Myocardial Fibrosis: An Angiotensin II Infusion Model in Mice

AIMS: Myocardial fibrosis contributes to the development of heart failure. Activated Protein C (aPC) is a circulating anticoagulant with anti-inflammatory and cytoprotective properties. Using a model of myocardial fibrosis second to Angiotensin II (AngII) infusion, we investigated the novel therapeu...

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Detalhes bibliográficos
Main Authors: Sopel, Mryanda J., Rosin, Nicole L., Falkenham, Alec G., Bezuhly, Michael, Esmon, Charles T., Lee, Timothy D. G., Liwski, Robert S., Légaré, Jean-Francois
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446915/
https://ncbi.nlm.nih.gov/pubmed/23029168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045663
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