Phospholipase D2-dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid

Cyclic phosphatidic acid (1-acyl-2,3-cyclic-glycerophosphate, CPA), one of nature’s simplest phospholipids, is found in cells from slime mold to humans and has largely unknown function. We find here that CPA is generated in mammalian cells in a stimulus coupled-manner by Phospholipase D2 (PLD2), and...

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Autori principali: Tsukahara, Tamotsu, Tsukahara, Ryoko, Fujiwara, Yuko, Yue, Junming, Cheng, Yunhui, Guo, Huazhang, Bolen, Alyssa, Zhang, Chunxiang, Balazs, Louisa, Re, Fabio, Du, Guangwei, Frohman, Michael A., Baker, Daniel L., Parrill, Abby L., Uchiyama, Ayako, Kobayashi, Tetsuyuki, Murakami-Murofushi, Kimiko, Tigyi, Gabor
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446787/
https://ncbi.nlm.nih.gov/pubmed/20705243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.022
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