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Phospholipase D2-dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid
Cyclic phosphatidic acid (1-acyl-2,3-cyclic-glycerophosphate, CPA), one of nature’s simplest phospholipids, is found in cells from slime mold to humans and has largely unknown function. We find here that CPA is generated in mammalian cells in a stimulus coupled-manner by Phospholipase D2 (PLD2), and...
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Main Authors: | , , , , , , , , , , , , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
2010
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3446787/ https://ncbi.nlm.nih.gov/pubmed/20705243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.022 |
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