K(+) Conduction and Mg(2+) Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance

Potassium channels exhibit a large diversity of single-channel conductances. Shaker is a low-conductance K-channel in which Pro475→Asp, a single-point mutation near the internal pore entrance, promotes 6- to 8-fold higher unitary current. To assess the mechanism for this higher conductance, we measu...

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Detalhes bibliográficos
Main Authors: Moscoso, Cristian, Vergara-Jaque, Ariela, Márquez-Miranda, Valeria, Sepúlveda, Romina V., Valencia, Ignacio, Díaz-Franulic, Ignacio, González-Nilo, Fernando, Naranjo, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446664/
https://ncbi.nlm.nih.gov/pubmed/22995492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.08.015
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