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K(+) Conduction and Mg(2+) Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance
Potassium channels exhibit a large diversity of single-channel conductances. Shaker is a low-conductance K-channel in which Pro475→Asp, a single-point mutation near the internal pore entrance, promotes 6- to 8-fold higher unitary current. To assess the mechanism for this higher conductance, we measu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3446664/ https://ncbi.nlm.nih.gov/pubmed/22995492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.08.015 |
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