Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

INTRODUCTION: The longitudinal degradation mechanism of extracellular matrix (ECM) in the interbertebral disc remains unclear. Our objective was to elucidate catabolic and anabolic gene expression profiles and their balances in intervertebral disc degeneration using a static compression model. METHO...

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Hauptverfasser: Yurube, Takashi, Takada, Toru, Suzuki, Teppei, Kakutani, Kenichiro, Maeno, Koichiro, Doita, Minoru, Kurosaka, Masahiro, Nishida, Kotaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446417/
https://ncbi.nlm.nih.gov/pubmed/22394620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3764
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