Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis

INTRODUCTION: Rheumatoid arthritis (RA) is associated with hypogalactosylation of immunoglobulin G (IgG). We examined whether a proxy measure for galactosylation of IgG N-glycans could predict response to therapy or was differentially affected by methotrexate (MTX) or TNF blockade. METHODS: Using a...

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Main Authors: Ercan, Altan, Cui, Jing, Hazen, Melissa M, Batliwalla, Franak, Royle, Louise, Rudd, Pauline M, Coblyn, Jonathan S, Shadick, Nancy, Weinblatt, Michael E, Gregersen, Peter, Lee, David M, Nigrovic, Peter A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446410/
https://ncbi.nlm.nih.gov/pubmed/22390545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3756
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