Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms

BACKGROUND: Complex diseases are associated with altered interactions between thousands of genes. We developed a novel method to identify and prioritize disease genes, which was generally applicable to complex diseases. RESULTS: We identified modules of highly interconnected genes in disease-specifi...

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Bibliografiske detaljer
Main Authors: Barrenäs, Fredrik, Chavali, Sreenivas, Alves, Alexessander Couto, Coin, Lachlan, Jarvelin, Marjo-Riitta, Jörnsten, Rebecka, Langston, Michael A, Ramasamy, Adaikalavan, Rogers, Gary, Wang, Hui, Benson, Mikael
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446318/
https://ncbi.nlm.nih.gov/pubmed/22703998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-6-r46
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