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Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

Human lung tumors PR310 and PR371 maintained in nude mice contain activated c-K-ras oncogenes detectable by the ability of their DNAs to induce the morphological transformation of NIH 3T3 mouse fibroblasts. Using phage libraries constructed with DNA from NIH 3T3 mouse fibroblast transformants, we ha...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nakano, H, Yamamoto, F, Neville, C, Evans, D, Mizuno, T, Perucho, M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344612/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6320174/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.1.71
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