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Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors
P-Glycoprotein (P-gp, ABCB1) plays a significant role in determining the ADMET properties of drugs and drug candidates. Substrates of P-gp are not only subject to multidrug resistance (MDR) in tumor therapy, they are also associated with poor pharmacokinetic profiles. In contrast, inhibitors of P-gp...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3445814/ https://ncbi.nlm.nih.gov/pubmed/22595422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.03.045 |
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