Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis

BACKGROUND: Optimal treatment for nonalcoholic steatohepatitis (NASH) has not yet been established, particularly for individuals without diabetes. We examined the effects of metformin, commonly used to treat patients with type 2 diabetes, on liver pathology in a non-diabetic NASH mouse model. METHOD...

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Autores principales: Kita, Yuki, Takamura, Toshinari, Misu, Hirofumi, Ota, Tsuguhito, Kurita, Seiichiro, Takeshita, Yumie, Uno, Masafumi, Matsuzawa-Nagata, Naoto, Kato, Ken-ichiro, Ando, Hitoshi, Fujimura, Akio, Hayashi, Koji, Kimura, Toru, Ni, Yinhua, Otoda, Toshiki, Miyamoto, Ken-ichi, Zen, Yoh, Nakanuma, Yasuni, Kaneko, Shuichi
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445596/
https://ncbi.nlm.nih.gov/pubmed/23028442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043056
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