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Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

Frontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically heterogeneous. Three major proteins are implicated in its pathogenesis. About half of cases are characterized by depositions of the microtubule associated protein, tau (FTLD-tau). In most of the remaining cases, d...

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Autores principales: Halliday, Glenda, Bigio, Eileen H., Cairns, Nigel J., Neumann, Manuela, Mackenzie, Ian R. A., Mann, David M. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445027/
https://ncbi.nlm.nih.gov/pubmed/22878865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-1030-4
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