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Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: Identification of functional themes

The genetic basis for virulence in influenza virus is largely unknown. To explore the mutational basis for increased virulence in the lung, the H3N2 prototype clinical isolate, A/HK/1/68, was adapted to the mouse. Genomic sequencing provided the first demonstration, to our knowledge, that a group of...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Proc Natl Acad Sci U S A
Ngā kaituhi matua: Brown, E. G., Liu, H., Kit, L. Chang, Baird, S., Nesrallah, M.
Hōputu: Artigo
Reo:Inglês
I whakaputaina: National Academy of Sciences 2001
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34447/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11371620/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.111165798
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