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Second site mutation in the virus envelope expands the host range of a cytopathic variant of Moloney murine leukemia virus

Spl574 MLV (murine leukemia virus) is a variant of Moloney ecotropic MLV (MoMLV) that is cytopathic in Mus dunni cells and restricted by other mouse cells. Its host range and cytopathicity are due to a mutation, S82F, at a site critical for binding to the CAT-1 receptor. To identify residues that af...

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Main Authors: Ferrarone, John, Knoper, Ryan C., Li, Randolph, Kozak, Christine A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444676/
https://ncbi.nlm.nih.gov/pubmed/22835818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.06.031
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