Alternative Nucleophilic Substrates for the Endonuclease Activities of Human Immunodeficiency Virus Type 1 Integrase

Retroviral integrase can use water or some small alcohols as the attacking nucleophile to nick DNA. To characterize the range of compounds that human immunodeficiency virus type 1 integrase can accommodate for its endonuclease activities, we tested 45 potential electron donors (having varied size an...

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Main Authors: Ealy, Julie B., Sudol, Malgorzata, Krzeminski, Jacek, Amin, Shantu, Katzman, Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444636/
https://ncbi.nlm.nih.gov/pubmed/22910593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.07.022
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