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Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus
We use a small animal model, based on guinea pigs infected with a non-pathogenic Pichinde virus (PICV), to understand the virulence mechanisms of arenavirus infections in the hosts. PICV P2 strain causes a mild febrile reaction in guinea pigs, while P18 causes severe disease with clinical and pathol...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444631/ https://ncbi.nlm.nih.gov/pubmed/22877842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.07.009 |
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