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Local Effects of Regulatory T Cells in MUC1 Transgenic Mice Potentiate Growth of MUC1 Expressing Tumor Cells In Vivo

MUC1 transgenic (MUC1.Tg) mice have widely been used as model recipients of cancer immunotherapy with MUC1. Although MUC1.Tg mice have previously been shown to be immunologically tolerant to MUC1, the involvement of regulatory T (Treg) cells in this phenotype remains unclear. Here, we showed that nu...

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Библиографические подробности
Главные авторы: Sugiura, Daisuke, Denda-Nagai, Kaori, Takashima, Mitsuyo, Murakami, Ryuichi, Nagai, Shigenori, Takeda, Kazuyoshi, Irimura, Tatsuro
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444443/
https://ncbi.nlm.nih.gov/pubmed/23028615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044770
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