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A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4

MCC-555 is a novel PPARα/γ dual ligand of the thiazolidinedione class and was recently developed as an anti-diabetic drug with unique properties. MCC-555 also has anti-proliferative activity through growth inhibition and apoptosis induction in several cancer cell types. Our group has shown that MCC-...

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Hlavní autoři: Min, Kyung-Won, Zhang, Xiaobo, Imchen, Temjenmongla, Baek, Seung Joon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443873/
https://ncbi.nlm.nih.gov/pubmed/22750490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.06.014
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