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Anti-angiogenic therapy increases intratumoral adenovirus distribution by inducing collagen degradation

Conditionally replicating adenoviruses (CRAd) are a promising class of gene therapy agents that can overcome already known glioblastoma (GBM) resistance mechanisms but have limited distribution upon direct intratumoral (i.t.) injection. Collagen bundles in the extracellular matrix (ECM) play an impo...

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Detalhes bibliográficos
Main Authors: Thaci, Bart, Ulasov, Ilya V., Ahmed, Atique U., Ferguson, Sherise D., Han, Yu, Lesniak, Maciej S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443547/
https://ncbi.nlm.nih.gov/pubmed/22673390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2012.42
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