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hESC-Derived Cardiomyocytes Electrically Couple and Suppress Arrhythmias in Injured Hearts

Transplantation studies in mice and rats have shown that human embryonic stem cell-derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts(1–3), but two critical issues related to their electrophysiological behavior in vivo remain unresolved. First, the risk of arrhythmias fol...

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Hlavní autoři: Shiba, Yuji, Fernandes, Sarah, Zhu, Wei-Zhong, Filice, Dominic, Muskheli, Veronica, Kim, Jonathan, Palpant, Nathan J., Gantz, Jay, Moyes, Kara White, Reinecke, Hans, Van Biber, Benjamin, Dardas, Todd, Mignone, John L., Izawa, Atsushi, Hanna, Ramy, Viswanathan, Mohan, Gold, Joseph D., Kotlikoff, Michael I., Sarvazyan, Narine, Kay, Matthew W., Murry, Charles E., Laflamme, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443324/
https://ncbi.nlm.nih.gov/pubmed/22864415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11317
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