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SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas

The increased expression of SIRT1 has recently been identified in numerous human tumors and a possible correlation with c-Myc oncogene has been proposed. However, it remains unclear whether SIRT1 functions as an oncogene or tumor suppressor. We sought to elucidate the role of SIRT1 in liver cancer u...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jang, Kyu Yun, Noh, Sang Jae, Lehwald, Nadja, Tao, Guo-Zhong, Bellovin, David I., Park, Ho Sung, Moon, Woo Sung, Felsher, Dean W., Sylvester, Karl G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443243/
https://ncbi.nlm.nih.gov/pubmed/23024800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045119
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