Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents

DNA-damaging agents (DDAs) constitute the backbone of treatment for most human tumors. Here we used the National Cancer Institute Antitumor Cell Line Panel (the NCI-60) to identify predictors of cancer cell response to topoisomerase I (Top1) inhibitors, a widely used class of DDAs. We assessed the N...

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Autors principals: Zoppoli, Gabriele, Regairaz, Marie, Leo, Elisabetta, Reinhold, William C., Varma, Sudhir, Ballestrero, Alberto, Doroshow, James H., Pommier, Yves
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443151/
https://ncbi.nlm.nih.gov/pubmed/22927417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205943109
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